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Search Results for " stem cell factor "

Targets Recommended: c-Kit

8

抑制剂 & 化合物

2

天然产物

23

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9689	M4205	c-Kit	Tyrosine Kinase/Adaptors
	M4205 是一种 c-Kit 抑制剂，对外显子 11、13、17 中的 c-Kit 突变具有高活性。
T6711	Tyrphostin AG1296 Tyrphostin AG 1296,AG 1296	Apoptosis; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1296 (Tyrphostin AG 1296) 抑制人PDGF α和β受体以及相关干细胞因子受体的信号传导，是一种选择性血小板衍生生长因子受体抑制剂，IC50值为 0.8 μM。
T1776L	Plerixafor octahydrochloride 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl	Virus Protease; HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。
T16680	PTC-028	Apoptosis; BMI-1	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	PTC-028 是一种口服有效的干细胞因子 BMI-1的抑制剂，可下调 BMI-1，诱导 caspase 介导的细胞凋亡。它选择性地抑制癌细胞，可用于治疗卵巢癌。
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T15197	Echinomycin Quinomycin A,NSC-13502	Others	Others
	Echinomycin is a cell-permeable hypoxia-inducible factor-1 (HIF-1) DNA-binding activity inhibitor. Echinomycin selectively inhibits the cancer stem cells (CSCs; IC50: 29.4 pM).
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T71400	Quizartinib HCl
	Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell pro...

化合物

Cat.No: T9689

Target: c-Kit

Tyrphostin AG1296

Cat.No: T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Plerixafor octahydrochloride

Cat.No: T1776L

Synonym: 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl

Target: Virus Protease, HIV Protease, CXCR

Cat.No: T16680

Target: Apoptosis, BMI-1

Cat.No: T10904

Target: Wnt/beta-catenin

Cat.No: T15197

Synonym: Quinomycin A,NSC-13502

Target: Others

Cat.No: T71576

Quizartinib HCl

Cat.No: T71400

Cat. No.	Product Name	Target	Signaling Pathways
T6943	Picropodophyllin AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂，IC50为1 nM。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。

天然产物

Picropodophyllin

Cat.No: T6943

Synonym: AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素

Target: Apoptosis, IGF-1R

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel fa...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPJ-01470	SCF Protein, Human, Recombinant Mast Cell Growth Factor,c-Kit ligand,KITLG...	Human	E. coli
	Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His) Mast cell growth factor,Il3,Multipotential...	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) CRISTIN1,THSD2,R-spondin 3,PWTSR	Human	HEK293 Cells
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s...
TMPH-02576	TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation.
TMPH-02316	YJEFN3 Protein, Human, Recombinant	Human	E. coli
	May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progeni...
TMPY-03968	Secretogranin II Protein, Human, Recombinant (His) EM66,SgII,SN,CHGC,secretogranin II	Human	HEK293 Cells
	Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel...
TMPJ-00123	FLT3LG Protein, Mouse, Recombinant (His) Fms-related tyrosine kinase 3 ligand (Flt3L),Flt3 ligand,SL ...	Mouse	HEK293 Cells
	Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and colony stimulating factor. Flt3L synergizes well with a number of other colony stimulating factors and interleukins. Flt3L stimulates the proliferation and differentiation of various blood cell progentiors by activating FLT3.
TMPJ-00879	HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His) Homeobox protein Hox-2.6,HOX2F,HOXB4,Homeobox protein Hox-2F...	Human	E. coli
	Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation ...
TMPJ-00835	FGF-4 Protein, Mouse, Recombinant HSTF1,HST-1,FGF4,FGF-4,HBGF-4,Fibroblast growth factor	Mouse	E. coli
	Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPH-01895	POU5F1 Protein, Human, Recombinant (B2M & His)	Human	E. coli
	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. POU5F1 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 52.6 kDa and the accession number is Q...
TMPJ-00091	G-CSF Protein, Mouse, Recombinant (His) Csf3,G-CSF,Granulocyte colony-stimulating factor,集落...	Mouse	HEK293 Cells
	Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of ...
TMPJ-00080	IL-11 Protein, Human, Recombinant (P. pastoris) 白细胞介素,Oprelvekin,Adipogenesis Inhibitory Factor,白介素...	Human	P. pastoris (Yeast)
	Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its recepto...
TMPY-01583	ALDH1A1 Protein, Human, Recombinant (His) ALDH11,ALDC,PUMB1,ALDH-E1,HEL-S-53e,HEL-9,aldehyde dehydroge...	Human	E. coli
	Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases f...
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His) eIF3 p36,eIF3i,eIF-3-beta,Eukaryotic translation initiation ...	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPH-03288	EIF3I Protein, Rat, Recombinant (His) eIF3i,Eif3s2,eIF-3-beta,Eukaryotic translation initiation	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPY-01783	SMOC1 Protein, Human, Recombinant (His) OAS,SPARC related modular calcium binding 1	Human	HEK293 Cells
	SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...
TMPJ-01177	NOV/CCN3 Protein, Mouse, Recombinant (His) CCN family member 3,Nephroblastoma-overexpressed gene protei...	Mouse	HEK293 Cells
	NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and ...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...

重组蛋白

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

SCF Protein, Human, Recombinant

Cat.No: TMPJ-01470

Species: Human

Expression System: E. coli

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

IL-3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00051

Species: Mouse

Expression System: HEK293 Cells

R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)

Cat.No: TMPY-02115

Species: Human

Expression System: HEK293 Cells

TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02576

Species: Mouse

Expression System: E. coli

YJEFN3 Protein, Human, Recombinant

Cat.No: TMPH-02316

Species: Human

Expression System: E. coli

Secretogranin II Protein, Human, Recombinant (His)

Cat.No: TMPY-03968

Species: Human

Expression System: HEK293 Cells

FLT3LG Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00123

Species: Mouse

Expression System: HEK293 Cells

HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)

Cat.No: TMPJ-00879

Species: Human

Expression System: E. coli

FGF-4 Protein, Mouse, Recombinant

Cat.No: TMPJ-00835

Species: Mouse

Expression System: E. coli

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

POU5F1 Protein, Human, Recombinant (B2M & His)

Cat.No: TMPH-01895

Species: Human

Expression System: E. coli

G-CSF Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00091

Species: Mouse

Expression System: HEK293 Cells

IL-11 Protein, Human, Recombinant (P. pastoris)

Cat.No: TMPJ-00080

Species: Human

Expression System: P. pastoris (Yeast)

ALDH1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01583

Species: Human

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03289

Species: Rat

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (His)

Cat.No: TMPH-03288

Species: Rat

Expression System: Baculovirus Insect Cells

SMOC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01783

Species: Human

Expression System: HEK293 Cells

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

NOV/CCN3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01177

Species: Mouse

Expression System: HEK293 Cells

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

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